,
Anirudha Singh, PhD

Assistant Professor
Department of Urology
Brady Urological Institute
Johns Hopkins University School of Medicine

Secondary appointments with
Department of Chemical & Biomolecular Engineering
Whiting School of Engineering, and
Translational Tissue Engineering Center of
Wilmer Eye Institute and
Department of Biomedical Engineering
Johns Hopkins University
Address:
Translational Tissue Engineering Center
Robert H. & Clarice Smith Building, Room 5001R,
Wilmer Eye Institute,
400 N Broadway, Baltimore, MD-21231


Office: 330-780-5733

Email: asingh29@jhu.edu

Fax: 410-614-6840

Dr. Singh received his Bachelors of Engineering (B. E) in Polymer Engineering from Birla Institute of Technology, Ranchi, India (2001), his Masters of Technology (M. Tech) from Indian Institute of Technology, New Delhi, India (2003) and his Ph. D in Polymer Science from the University of Akron, Ohio (2008). He was a Maryland Stem Cell Research Foundation postdoctoral fellow (MSCRF, 2010-12) and an Arthritis Foundation (AF, 2012-14) postdoctoral fellow at the Translational Tissue Engineering Center, Department of Biomedical Engineering, Johns Hopkins University. Before, his postdoctoral research fellowships, he worked in General Electric (GE), now SABIC-IP, as a product developer (2008-09). Dr. Singh joined the Department of Urology, Brady Urological Institute, at the Johns Hopkins School of Medicine as an instructor in 2014 and as a full time Assistant Professor since July 1st, 2015 with a secondary appointment in the Dept. of Chemical and Biomolecular Engineering, Johns Hopkins University.

Dr. Singh's research interest is in finding clinically relevant simple solutions to complex health problems through translational scientific and engineering approaches. One of the main goals of his research group is "Regenerative Urology", where the research is focused on design, fabrication and development of functional urinary tissues and organs, such as urinary diversion conduit, ureter and bladder. His group applies major themes including, biomaterials, polymer chemistry, stem cell and tissue engineering for regenerating biologically and mechanically functional tissues/organs, specifically urological tissues and organs, musculoskeletal and ocular tissues. His group also studies a variety of biomaterials-based deployment strategies that provide spatiotemporal delivery of biologics, including peptides, cells, nanomaterials, polymers and small molecules to augment endogenous repair responses and target degenerative diseases.

Research Interests: Polymer Chemistry, Stem Cells, Biomaterials, Regenerative Urology, Tissue Engineering, and Design & Fabrication.



Education


Education and Training

2001     B. Engineering, Polymer Engineering, Birla Institute of Technology, India  
2003     M. Technology (course), Polymer Science & Technology, Indian Institute of Technology, New Delhi, India
2003     M. Technology (thesis), Institute for Plastics processing, RWTH, Aachen, Germany                        
2008     Ph. D., Polymer Science (Chemistry), University of Akron, Ohio
2010     Postdoctoral Fellow, Biomedical Engineering, Johns Hopkins University

Professional Experience

2000     Summer Intern, Process Technology, Reliance Industries Limited
2008     Product Developer, General Electric (GE plastics)                              
2014     Instructor, Urology, Johns Hopkins University
2014     Instructor, Biomedical Engineering, Johns Hopkins University

 



Publications

 Free access to abstracts at PubMed

RESEARCH ACTIVITIES
PublicationsPeer-reviewed Original Science Research [*shared 1st author]                                                        

  1. Chaicharoen K, Polce JM, Singh A, Pugh C, Wesdemiotis C. Characterization of linear and branched polyacrylates by tandem mass spectrometry. Anal Bioanal Chem. 2008; 392:595-607.
  2. Pugh C, Raveendra B, Singh A, Reichel S, Garcia G. Design and regioselective synthesis of (2-bromo-2-alkoxycarbonyl)ethyl acrylates as inimers for hyperbranched (co)polyacrylates. SynLett. 2010; 13:1947-1950.
  3. Pugh C, Singh A. Synthesis of hyperbranched polyacrylates by a chloroinimer approach. Macromolecules. 2010; 43:5222-5232.
  4. Singh A, Elisseeff J. Biomaterials for stem cell differentiation. J Mater Chem. 2012; 20:8832-8847.
  5. Deans L*, Singh A*, Elisseeff J. Regulating gene-networks in 3D biomaterials. Proc Nat Acad Sci USA. 2012; 109:15217-15277.
  6. Zhan J*, Singh A*, Elisseeff J. Multifunctional aliphatic polyester for tissue engineering applications. Biomatter. 2012; 2:202-212.
  7. Singh A, Zhan J, Elisseeff J. Multifunctional modular poly(ethylene glycol) hydrogels for stem cell differentiation. Adv Funct Mater. 2013; 5:575-582.
  8. Singh A, Deans L, Elisseeff J. Photomodulation of gene expression in hydrogels. ACS MacroLetters. 2013; 2:269-272.
  9. Beck J*, Singh A*, Rothenberg A, Elisseeff J. The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination. Biomaterials. 2013; 34:9486-9495.
  10. Singh A, Corvelli M, Unterman S, Elisseeff J. Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid. Nat Mater. 2014; 13:988-995. (also Editor's choice in Science Translational Medicine)
  11. Singh A, Li P, Elisseeff J. Surface-bound hyaluronic acid enhances water retention in contact lenses. Cont Lens Anterior Eyes. 2014; 38:79-84.
  12. Corvelli M, Singh A, Che B, Saeui C, Elisseeff J. Biodynamic performance of hyaluronic acid versus synovial fluid of the knee as a therapy for osteoarthritis. Methods. 2015; Epub ahead of print.
  13. Chakraborty A, Patni P, Suhag D, Saini G, Singh A, Chakrabarti S, Mukherjee M. N-doped carbon nanosheets with antibacterial activity: mechanistic insight. RSC Advances. 2015; 5:23591-23598.
  14. Reid B, Gibson M, Singh A, Taube J, Furlong C, Murcia M, Elisseeff J. PEG hydrogel degradation and the role of the surrounding tissue environment.  J Tissue Eng Regen Med. 2015; 9:315-318.
  15. Suhag D, Singh A, Chattopadhyay S, Chakrabarti S, Mukherjee M. Hydrothermal synthesis of nitrogen doped graphene nanosheets from carbon nanosheets with enhanced electrocatalytic properties. RSC Advances. 2015; 5; 39705-39713.

In Press

  1. Singh A, Zhan J, Elisseeff J.  Modulating chemistry of PEG hydrogels: effect of molecular composition and concentration on tissue development. J Tissue Eng Regen Med. 2015 (in press).
  2. Suhag D, Bhatia R, Das S, Shakeel A, Ghosh A, Singh A, Sinha OP, Chakrabarti S, Mukherjee M. Physically cross-linked pH-responsive hydrogels with tunable formulations for controlled drug delivery. RSC Advances. 2015 (in press).

Book Chapters

  1. Singh A, Polycarbonates in polycondensation reactions. Encyclopedia, Wiley publication, 2015.
  2. Kates M, Singh A, Matsui H, Steinberg GD, Smith NM, Schoenberg MP, Bivalacqua TJ. Tissue-engineered urinary conduits. Curr Urol Rep, 2015; 16:8.

Internet media

8/18/14 Engineering long-lasting joint lubrication by mimicking nature
http://www.hopkinsmedicine.org/news/media/releases/engineering_long_lasting_joint_lubrication_by_mimicking_nature .
8/19/14 Slippery material for lubricating joints inspired by nature
http://www.medicalnewstoday.com/articles/281212.php
5/1/15 Spotlight on research May 2015: Bioengineered compound may aid in treating osteoarthritic joints
http://www.niams.nih.gov/News_and_Events/Spotlight_on_Research/2015/osteoarthritis.asp
10/22/14 Editors' choice "Elbow Greece" - Spiller KL, Elbow Grease. Sci Transl Med. 2014; 6:259ec180
http://stm.sciencemag.org/content/6/259/259ec180.full?sid=aebedb02-8515-444c-a67d-871183f3cbe5



Inventions, Patents, Copyrights

4/17/08  Singh A, Pugh C. Synthesis of inimers and hyperbranched polymers based on 2-halo-3-hydroxypropionic acid, 2-halo-3-hydroxybutyric acid and their derivatives. Issued Patent: WO 2008/045299 B2.
12/27/11  Malinoski J, Singh A, Maruvada S. Transparent thermoplastic compositions having high flow and ductility and articles prepared therefrom. Issued Patent: US8084134 B2.
4/25/14   Elisseeff J, Guo Q, Majumdar S, Singh A. Compositions comprising cyclodextrin incorporated collagen matrices for use in biomedical applications. Pending for approval: US2014/61/984,328.
5/8/14 Elisseeff J, Beachley V, Singh A, Li P, McDonnell P. Contact lens surface modification for hyaluronic acid accumulation and retention.  Pending for approval: US2013/067970, WO2014071132 A1.
10/7/14 Singh A, Zhan J, Elisseeff J. Multifunctional biomaterials with tunable properties for directed stem cell differentiation. JHU P11696-01.
1/22/15 Singh A, Unterman S, Corvelli M, Elisseeff J. Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications. Pending approval: US2014/046796, WO/2015/009787 A1.
4/4/15 Singh A. Scaffold design and process for developing tissue-engineered organs with hollow structures.    JHU C13509.
6/1/15  Singh A, Lee D, Lu N, Elisseeff J. An eye-drop technology with enhanced hyaluronic acid retention and delivery to ocular tissues. US provisional 62207419.

 



Memberships

American Chemical Society (ACS)
Society for Biomaterials (SFB)
Biomedical Engineering Society (BMES)
Tissue Engineering & Regenerative Medicines (TERMIS)
Material Research Society (MRS)
Association for Research in Vision and Ophthalmology (ARVO)
International Cartilage Research Society (ICRS)
International Society for Hyaluronan Sciences (ISHAS)


Awards & Honors

2001 Gold-medalist in undergraduate studies, BIT Mesra, Ranchi, India
2001 2nd All India Rank in Graduate Aptitude Test in Engineering (GATE), India
2002 DAAD Scholar of German Masters Sandwich Exchange Programme, India
2004 1st to pass all the cumulative exams (in PhD), Akron, Ohio
2006 Best poster presentation award on company sponsor's day (Akron), Ohio
2006 Top choice for the Eastman chemicals' best graduate student award at the University of Akron, Ohio
2008 Management award at GE plastics (SABIC-IP) for manufacturing a new polycarbonate copolymer
2012 Best oral presenter at Materials Research Society (Biomaterials for Tissue Eng.), Boston, MA
2012 INBT-Featured researcher at the Annual symposium of Institute for NanoBio Technologies, JHU